abstract：:The long-term effects of partial denervation on the muscle fiber cross-sectional area, degree of axonal sprouting, and end-plate morphology were examined 1, 3, 6, 9, and 12 months postsurgery in rat plantaris muscle. After 1 month of partial denervation, mean cross-sectional areas of type I and type II myofibers were ...

journal_title：Experimental neurology

authors： Pachter BR,Eberstein A

更新日期：1992-06-01 00:00:00

abstract：:Outcome following stroke is difficult to measure because the behavioral response to infarction is variable. We hypothesized that cognitive function, such as spatial learning, may be a reproducible and sensitive outcome variable. We developed an animal model of multifocal cerebral ischemia in order to study the effects...

journal_title：Experimental neurology

authors： Lyden PD,Zivin JA,Chabolla DR,Jacobs MA,Gage FH

更新日期：1992-05-01 00:00:00

abstract：:The conditioned corral preference paradigm was used to assess reinforcing effects of substance P (SP) and its N- and C-terminal fragments injected unilaterally into the region of the nucleus basalis magnocellularis (NBM) in rats. Behavioral testing was carried out in a circular open field, consisting of 4 quadrants eq...

journal_title：Experimental neurology

authors： Hasenöhrl RU,Gerhardt P,Huston JP

更新日期：1992-02-01 00:00:00

abstract：:The aim of this study was to compare the physiological properties of single neurons in the glabrous (G) and heterogeneous (H) subdivisions of primary somatosensory digit 3 cortex of adult raccoons. Extracellular recordings were obtained from 50 G neurons whose receptive fields (RFs) were confined to the glabrous skin ...

journal_title：Experimental neurology

authors： Doetsch GS,Stoney SD Jr,Hauge DH

更新日期：1992-02-01 00:00:00

abstract：:GAP-43 is a neuronal protein whose synthesis is elevated during developmental and regenerative axon growth. We propose that one consequence of this increased synthesis may be the delivery of calmodulin-like proteins to the distal portions of the growing axon at an increased velocity; this is because calmodulin, which ...

journal_title：Experimental neurology

authors： Spencer S,Willard MB

更新日期：1992-01-01 00:00:00

abstract：:Adult New Zealand Red (NZR) rabbits were used to determine if the techniques developed in the rat to transplant sheets of photoreceptors could be adapted to larger eyes of the rabbit. Adult donor NZR rabbit retina was cut into small strips, oriented, and drawn up in a small and flat polyethylene tube. By transscleral ...

journal_title：Experimental neurology

authors： Schuschereba ST,Silverman MS

更新日期：1992-01-01 00:00:00

abstract：:The inferior colliculus was selected as a brain stem site for study of neural grafting and identification of calcium binding proteins. Unilateral ablation sites of eight midbrain inferior colliculus in adult Long-Evans rats were implanted with E17-18 caudal tectum. After 2 to 9 months animals were sacrificed and secti...

journal_title：Experimental neurology

authors： Coleman JR,McDonald AJ,Pinek B,Zrull MC

更新日期：1992-01-01 00:00:00

abstract：:Microfilaments (MFs) play an important role in wound healing and other regenerative events. The purpose of this study was to characterize changes in the distribution of MFs in traumatized auditory epithelia and compare these changes between avian (regenerating) and mammalian (nonregenerating) ears. Chicks and guinea p...

journal_title：Experimental neurology

authors： Raphael Y,Altschuler RA

更新日期：1992-01-01 00:00:00

abstract：:The tibial functional index has been employed to assess functional recovery in rats following nerve repair by direct coaptation under tension or by grafting. Recovery after direct repair of small to moderate gap sizes was better than that after grafting. ...

journal_title：Experimental neurology

authors： Wong AY,Scott JJ

更新日期：1991-12-01 00:00:00

abstract：:Polymerized collagen rolls enclosing Schwann cells (SCs) raised in culture were grafted into cystic cavities formed after lesioning the thoracic spinal cord of adult rats. Axons were already present within the graft by 14 days after implantation and both ensheathed and myelinated axons were numerous by 28 days. This a...

journal_title：Experimental neurology

authors： Paino CL,Bunge MB

更新日期：1991-11-01 00:00:00

abstract：:Both alpha- and beta-adrenergic receptors (ARs) are involved in the facilitation of the monosynaptic jaw-closing reflex in the trigeminal motor nucleus (MoV) caused by norepinephrine (NE). The amplitude of muscle spindle afferent-evoked EPSPs in masseter motor neurons is 65% greater when noradrenergic axons to the mot...

journal_title：Experimental neurology

authors： Shao YP,Sutin J

更新日期：1991-11-01 00:00:00

abstract：:An in vivo assay was developed for long-term analyses of Schwann cells at the single cell level. Schwann cells were isolated from sciatic nerves and labeled with the fluorescent gold label Fluoro-Gold. Cells were then transplanted into severed sciatic nerves of young adult rats. Gold-labeled Schwann cells, identified ...

journal_title：Experimental neurology

authors： Daniloff JK

更新日期：1991-10-01 00:00:00

abstract：:In the previous paper it was demonstrated that striatal dopamine (DA) D1 and D2 receptor subtypes and muscarinic M1 and M2 receptor subtypes show differing responses to lesions of the mesostriatal DA system. To examine this differential regulation further rats were given unilateral injections of 6-hydroxydopamine (6-O...

journal_title：Experimental neurology

authors： Joyce JN

更新日期：1991-09-01 00:00:00

abstract：:Monosialoganglioside GM1 prevents excitatory amino acid (EAA)-related neuronal death in cultured central nervous system (CNS) neurons and reduces the severity of acute brain damage in different experimental models of cerebral ischemia. Using a model of brain damage induced by intracerebroventricular administration of ...

journal_title：Experimental neurology

authors： Lipartiti M,Lazzaro A,Zanoni R,Mazzari S,Toffano G,Leon A

更新日期：1991-09-01 00:00:00

abstract：:Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus of the rat hippocampus following removal of specific afferents. In the present study we have examined the relation of synaptophysin immunoreactivity to the immunohistochemical staining pattern of GAP-43, a putative marker of neu...

journal_title：Experimental neurology

authors： Masliah E,Fagan AM,Terry RD,DeTeresa R,Mallory M,Gage FH

更新日期：1991-08-01 00:00:00

abstract：:The effect of frequency potentiation on the postsynaptic potential in granule cells was studied stimulating the perforant path in curarized and urethanized rats. At stimulation frequencies between 2.0-5.0 Hz, synaptic efficacy in eliciting an orthodromic action potential increased despite the hyperpolarization of the ...

journal_title：Experimental neurology

authors： Muñoz MD,Núñez A,García-Austt E

更新日期：1991-07-01 00:00:00

abstract：:The effect of sinusoidal magnetic field stimulation on regeneration of the rat sciatic nerve was studied. Rats were exposed, after crush lesioning of the nerve, between a pair of Helmholtz coils to a 50 Hz magnetic field of 0.2 mT or 0.4 mT, respectively. Regeneration of the sciatic nerve was measured by the "pinch te...

journal_title：Experimental neurology

authors： Rusovan A,Kanje M

更新日期：1991-06-01 00:00:00

abstract：:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...

journal_title：Experimental neurology

authors： Aoki F,Nakamura S

更新日期：1991-06-01 00:00:00

abstract：:Cholinergic neurons in the basal forebrain magnocellular complex (BFMC) respond to nerve growth factor (NGF) during development and in adult life, and it has been suggested that the administration of NGF might ameliorate some of the abnormalities that occur in neurological disorders associated with degeneration of thi...

journal_title：Experimental neurology

authors： Koliatsos VE,Applegate MD,Knüsel B,Junard EO,Burton LE,Mobley WC,Hefti FF,Price DL

更新日期：1991-05-01 00:00:00

abstract：:Infusions of an excitant amino acid, N-methyl-D-aspartate (NMDA) into the inferior colliculus (IC) render normal rats susceptible to audiogenic seizures (AGS) and/or spontaneous audiogenic-like seizures without tonic components. The excess excitant amino acid in the IC and the anticonvulsant effects of NMDA antagonist...

journal_title：Experimental neurology

authors： Browning RA,Wang C,Faingold CL

更新日期：1991-05-01 00:00:00

abstract：:Spinal axons in the larval sea lamprey regenerate following a complete spinal transection. It is not known whether regenerating growth cones require contact with cellular elements or whether the basement membrane and collagenous meninx primitiva which surround the spinal cord are sufficient for neurite out-growth. To ...

journal_title：Experimental neurology

authors： Lurie DI,Selzer ME

更新日期：1991-04-01 00:00:00

abstract：:Roles of protein kinases in mediating adaptive neuronal responses to activation of signal transduction pathways are well known. Recent findings suggest that kinases may also be involved in pathological processes in the nervous system. The present study employed cultured human cerebral cortical neurons to test the hypo...

journal_title：Experimental neurology

authors： Mattson MP

更新日期：1991-04-01 00:00:00

abstract：:The effects of sex differences and hormonal factors on the locomotor alterations following intrastriatal injections of quinolinic acid (QA) and the ability of fetal striatal transplants to reverse those effects were examined. Male, female, or ovariectomized female rats received bilateral injections of 150 nmol QA or v...

journal_title：Experimental neurology

authors： Emerich DF,Zubricki EM,Shipley MT,Norman AB,Sanberg PR

更新日期：1991-03-01 00:00:00

abstract：:Cross-species transplantation of dopamine-releasing cell lines protected against immune rejection by a semi-permeable synthetic membrane may provide a source of neurotransmitters for the treatment of Parkinson's disease. Experiments were carried out to assess whether polymer-encapsulated PC12 cells, a catecholaminergi...

journal_title：Experimental neurology

authors： Aebischer P,Tresco PA,Winn SR,Greene LA,Jaeger CB

更新日期：1991-03-01 00:00:00

abstract：:The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...

journal_title：Experimental neurology

authors： O'Hara TE Jr,Goshgarian HG

更新日期：1991-02-01 00:00:00

abstract：:Increased intercellular coupling has been implicated in contributing to the synchronization of discharges characteristic of epileptic foci. Using RNA blot analysis, the level of mRNA for the heart-type gap junction protein, connexin43, is shown to be elevated in samples of temporal lobe neocortex obtained at the time ...

journal_title：Experimental neurology

authors： Naus CC,Bechberger JF,Paul DL

更新日期：1991-02-01 00:00:00

abstract：:The axonal trajectories of inspiratory bulbospinal neurons were examined after deposition of the anterograde neuronal tracer phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventral respiratory group in rats. At the level of the phrenic nucleus, PHA-L-labeled bulbospinal axons crossed the midline of the spi...

journal_title：Experimental neurology

authors： Goshgarian HG,Ellenberger HH,Feldman JL

更新日期：1991-01-01 00:00:00

abstract：:The precise role of hypothalamic norepinephrine (NE) in the control of vasopressin (AVP) release has remained unclear, due to reports of both inhibitory and excitatory effects of NE and only a few studies with direct hypothalamic manipulations. The present study utilized a chronically implanted swivel brain cannula to...

journal_title：Experimental neurology

authors： Leibowitz SF,Eidelman D,Suh JS,Diaz S,Sladek CD

更新日期：1990-12-01 00:00:00

abstract：:Intrastriatal injection of excitatory amino acids, particularly quinolinic acid, has been proposed as an animal model of Huntington's disease. Such neurotoxic lesions of caudate-putamen result in marked dopamine type-1 (D1) receptor losses in the injected nuclei as well as in the ipsilateral substantia nigra pars reti...

journal_title：Experimental neurology

authors： Filloux F,Wagster MV,Folstein S,Price DL,Hedreen JC,Dawson TM,Wamsley JK

更新日期：1990-11-01 00:00:00

abstract：:The dependence of movement on visual information was compared for healthy individuals and Stage II-III patients with Parkinson's disease (PD). A time delay (0-1400 ms) was introduced into a visually guided motor tracking task which required the subject to maintain constant index finger position relative to a stationar...

journal_title：Experimental neurology

authors： Beuter A,Milton JG,Labrie C,Glass L,Gauthier S

更新日期：1990-11-01 00:00:00

abstract：:In monkeys, unilateral intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a useful model of hemiparkinsonism. To evaluate MPTP-induced neurochemical changes in vivo, brain microdialysis was employed to measure extracellular levels of dopamine and its metabolites in the neostriatum of...

journal_title：Experimental neurology

authors： Skirboll S,Wang J,Mefford I,Hsiao J,Bankiewicz KS

更新日期：1990-11-01 00:00:00

abstract：:Following a unilateral fimbria-fornix lesion, the delivery of nerve growth factor (NGF) to the ipsilateral lateral ventricle of the rat can prevent the lesion-induced loss of choline acetyltransferase (ChAT) expression in the ipsilateral medial septum and vertical diagonal band region. In the present study, the abilit...

journal_title：Experimental neurology

authors： Hoffman D,Wahlberg L,Aebischer P

更新日期：1990-10-01 00:00:00

abstract：:Systemic administration of the amphetamine derivative p-chloroamphetamine (PCA) causes degeneration of 5-HT axon terminals in rat brain. The present study was designed to determine whether PCA induces neurotoxic effects by a direct action on 5-HT axon terminals. PCA was administered by microinjection directly into the...

journal_title：Experimental neurology

authors： Berger UV,Molliver ME,Grzanna R

更新日期：1990-09-01 00:00:00

abstract：:We have studied the functional involvement of J1-160 and J1-180 in the interaction between oligodendrocytes and neurons, astrocytes, or L cells in short- and long-term adhesion assays using monoclonal antibodies directed against topographically distinct epitopes on the molecules. Whereas antibodies to mouse liver memb...

journal_title：Experimental neurology

authors： Morganti MC,Taylor J,Pesheva P,Schachner M

更新日期：1990-07-01 00:00:00

abstract：:This paper focuses on transient boundaries of glia and glycoconjugates during development of the mouse central nervous system (CNS). Lectin-bound glycoconjugates, glial fibrillary acidic protein, and the J1/tenascin glycoprotein are distributed coextensively within boundaries around developing substructural arrangemen...

journal_title：Experimental neurology

authors： Steindler DA,O'Brien TF,Laywell E,Harrington K,Faissner A,Schachner M

更新日期：1990-07-01 00:00:00

abstract：:We administered tetrahydroaminoacridine (THA), a cholinesterase inhibitor, to rats with bilateral nucleus basalis magnocellularis lesions and measured their performance in a spatial learning task. The subjects, 34 male Fischer-344 rats, received bilateral excitotoxic NBM lesions; 10 other rats served as unlesioned con...

journal_title：Experimental neurology

authors： Kwo-On-Yuen PF,Mandel R,Chen AD,Thal LJ

更新日期：1990-06-01 00:00:00

abstract：:We used [2-14C]deoxyglucose as a marker of increased metabolism of the hypoglossal nucleus after transection of its nerve. We studied this metabolism in 3-, 12-, and 24-month-old rats. We found an increase in glucose uptake in the control nucleus of 24-month-old rats which was significant when compared to that of 3-mo...

journal_title：Experimental neurology

authors： Singer PA,Mehler S

更新日期：1990-04-01 00:00:00

abstract：:A sample of 504 single neurons isolated in three curvilinear arrays of 10 closely spaced tracks in primary somatosensory and in pericruciate sensorimotor cortex was studied in two awake, restrained domestic cats. Modality sensitivity and receptive field size and location were assessed for each neuron, along with respo...

journal_title：Experimental neurology

authors： Slimp JC,Towe AL

更新日期：1990-01-01 00:00:00

abstract：:A host protein encoded by the gene specifying the scrapie amyloid precursor affects pathogenesis of the transmissible spongiform encephalopathies: Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker's syndrome (GSS), and kuru in man, and scrapie in animals. We found a mutation in this gene of two patients ...

journal_title：Experimental neurology

authors： Goldgaber D,Goldfarb LG,Brown P,Asher DM,Brown WT,Lin S,Teener JW,Feinstone SM,Rubenstein R,Kascsak RJ

更新日期：1989-11-01 00:00:00

abstract：:MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested for anticonvulsant effects in rats using two seizure models, coadministration of lithium and pilocarpine and administration of a high dose of pilocarpine alone. Three major results are reported. First, pretreatment with MK-801 produce...

journal_title：Experimental neurology

authors： Ormandy GC,Jope RS,Snead OC 3rd

更新日期：1989-11-01 00:00:00